The researchers in this experiment aimed to “Investigate the quantitative differentiation of pulmonary dendritic cells in smoker with or without chronic obstructive pulmonary disorder (COPD) to explore the possible role of dendritic cells in smokers suffering COPD” (Yan-wei, Yong-jiang, & Xian-sheng, 2010). Dendritic cells (DCs) are inflammatory cells that are considered to be the promoter of immune responses; knowing this the researchers hypothesized that DCs may play an important role in the development of the disease.
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Subjects were broken into three groups based on an illness gradient: (control group, smokers without airflow obstruction, and COPD group as determined by the Chinese Society of Respiratory Disease). Samples of alveolar tissue were taken from these three groups and studied using immunohistochemical staining and immunofluorescence confocal laser scanning. The results from the experiment are portrayed using a one-way analysis of variance, Pearson’s r coefficient, graphs, and scatter plots. The conclusion of the data showed that “The quantity of the DCs significantly increased in smokers with COPD compared with non-smokers or smokers without COPD” (Yan-wei et al., 2010).
A critical analysis of this article received a 31.5. The article was well put together and provided many up to date references as resources to give a better understanding of the research. The authors explained their methodologies in great detail and the production of their data was concise and easy to read. However, the study lacked when it came to representing a diverse population. The study also lacks in terms of providing evidence of the consent of the subjects and the evidence of the governing body of the experiment.
The research that was done in this experiment allowed scientist to develop new hypotheses concerning dendritic cells and their role in chronic diseases such as COPD. The links that were made with this research between dendritic cells, lung capacity, and cigarette smoke could potentially be the forefront of new treatments and earlier diagnoses for COPD victims.
Yan-wei, S., Yong-jian, X., & Xian-sheng, L. (2010). Quantitative differentiation of dendritic cells in lung tissues of smokers with and without chronic obstructive pulmonary disease. Chinese Medical Journal, 123(12). Retreived from http://www.cmj.org/Periodical/PDF/200481469383420.pdf