The Significance of Cross-Matching for Blood Transfusions

About this essay

Transfusion is vital for the patient if they have an illness, disease, medical condition or undergoing a surgery which loses blood or requires them to replace blood lost during an injury. Mistakes in cross-matching can occur if the wrong patient, IC or donor unit is given to the patient who requires transfusion. Pre-transfusion testing procedures consist of antibody screening, identification as well as cross-matching in blood transfusion establishments.

Clinically significant antibodies can cause haemolytic transfusion reactions. Antibody identification is critical for patients who require blood transfusions, it can detect the presence of any unsuspected antibodies moreover to ensure that the blood transfused is the compatible unit.

In cross-matching, the common things to check are the patient’s name, IC and the correct donor unit of blood is given to the patient. Severe adverse reactions may occur if the patient is given the wrong unit such as giving the wrong blood type or when a patient has alloantibodies or antibodies against certain blood antigens which can cause complications such as haemolytic transfusion reaction.

Get quality help now
Sweet V
Sweet V
checked Verified writer

Proficient in: Anatomy

star star star star 4.9 (984)

“ Ok, let me say I’m extremely satisfy with the result while it was a last minute thing. I really enjoy the effort put in. ”

avatar avatar avatar
+84 relevant experts are online
Hire writer

On the surface membrane of red blood cells, there are the ABO blood groups along with Rh antigens. To ensure that complications of transfusion do not occur, antibody screening is done to detect unexpected antibodies or alloantibodies.

When an agglutination is formed between antibodies and blood cell antigens in vivo, the production of alloantibodies will be formed. Alloimmunization happens after a second blood transfusion when antigens are recognized as foreign antigens. Examples of alloantibodies are Kell, Duffy, Kidd, MNS as well as Rh (D, C, E, d, c and e in the Fisher-race terminology).

Get to Know The Price Estimate For Your Paper
Number of pages
Email Invalid email

By clicking “Check Writers’ Offers”, you agree to our terms of service and privacy policy. We’ll occasionally send you promo and account related email

"You must agree to out terms of services and privacy policy"
Write my paper

You won’t be charged yet!

When these are detected, a Coombs Antibody Test (CAT) is done to ensure that there is no reaction between the patient’s serum and the donor’s blood. When there is no suitable donor blood to give, an order of donor blood will be made from Blood Transfusion Service.

Other products such as fresh frozen plasma, cryoprecipitate as well as platelet unit must be checked as well to ensure that the correct unit is given to the correct patient to ensure that there are no complications. Certain patients such as patients with an immune disorder, unborn babies and inherited immune disorder, has special requirements such as irradiated products (blood and platelets) must be given to them to prevent transfusion-related graft versus host disease.

Hence, doing a pre-transfusion check between blood components and patient to avoid administering the wrong donor unit to the patient and complications to the patient as well as wasting unnecessary cost.

Cite this page

The Significance of Cross-Matching for Blood Transfusions. (2023, Apr 04). Retrieved from

Live chat  with support 24/7

👋 Hi! I’m your smart assistant Amy!

Don’t know where to start? Type your requirements and I’ll connect you to an academic expert within 3 minutes.

get help with your assignment