Brain Alterations After Laparoscopic Sleeve Gastrectomy Study

In recent years, obesity has seriously endangered human health. Studies have found that obesity can cause many chronic diseases such as metabolic diseases, cardiovascular diseases, type II diabetes, and cancer. Among the many methods for treating obesity, bariatric surgery can effectively reduce body weight and be effective for a long time. Besides, abnormal brain function caused by obesity has also been improved. However, it is not clear whether the change in brain function caused by bariatric surgery only affects obese patients.

Therefore, this study selected a group of severely obese patientsobesepatients obeseplate experience to undergo laparoscopic Sleeve Gastrectomy (LSG) and a group of gastric cancer patients to undergo Gastric Surgery (GS). An analysis of variance (ANOVA) was performed on the Amplitude of Low-Frequency Fluctuation of both groups before and one month after surgery. Two groups of people were found to have significant interaction effects in the brain regions of the nucleus accumbens (NAc), dorsal unilateral prefrontal cortex (DLPFC), putamen (PUT), amygdala (AMY), and hippocampus (HIPP).

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After post-hoc tests by extracting ALFF value, The ALFF of NAc, PUT, AMY, and HIPP was significantly reduced in the LSG group one month after surgery, and the ALFF of DLPFC was significantly increased. Another group is just the opposite.

Introduction

In recent years, obesity or overweight has become a universal phenomenon in the world, causing serious harm to human health and social development. The number of obese people worldwide is increasing every year, and what is more alarming is that no country has succeeded in curbing the rise in obesity[1].

The United States is the world's largest economy, although the population is less than 5% of the world's total population, obesity accounted for 13% of the world's total obesity, obesity in the United States every year caused about 100,000 to 400,000 deaths. In 2008 alone, the cost of treating obesity and its complications in the United States amounted to the US $147 billion[2]. According to the World Health Organization, overweight and obesity seriously affect human health, leading to coronary heart disease, arthritis, stroke, dyslipidemia, sleep apnea syndrome, type 2 diabetes, cancer, and other diseases[3]. People's addiction to food is a major cause of obesity[4]. At the same time, high glucose and high fat intake can lead to a decrease in DAD2 receptors and the decrease in DAD2 sensitivity[5]. So at home and abroad, various ways of reducing weight were taken from different angles. The short-term curative effect of minimally invasive surgery for severe obesity or overweight is nearly 100%. Medium and long-term effective satisfaction reached 85%-97%. Weight loss surgery is the only long-term effective way to treat overweight or obesity[6]. Currently, minimally invasive weight loss surgery includes Adjustable Gastric Band (AGB), Sleeve Gastrectomy (LSG), and Roux-e-Y Gastric Bypass (RYGB)[7]. After the doctor's clinical practice found that LSG weight loss surgery is simpler, less risk of surgery, postoperative gastrointestinal physiology, and food digestion and normal people have no difference[8]. And compared with other minimally invasive weight loss surgery with significant weight loss effects, LSG weight loss surgery has the same significant effect[9]. At the same time, it was found that obesity patients' appetite for food and food intake decreased after weight loss surgery[10-11].

Methods: The functional magnetic resonance data scanned by the test was preprocessed by the DPARSF toolkit under the MATLAB platform. The specific preprocessing process is as folloobesethe the ws:

1. Slice Timing
2. RealigntheobeseRealign thethe  the the plattheplat  the  theNormalize
3. Smooth

Based on the DPARSF software of the plate the Matlab platform, ALFF analysis was performed on the pre-treated data of LSG operation group and gastric cancer operation group. Using the SPM software package, the variance analysis was performed on the ALFF of the two groups before and after the operation to find out the brain regions with significant cross-effects of brain activity before and after surgery in the weight loss surgery group and the gastric cancer operation group. Related brain regions. Subsequently, the ALFF values of the two groups before and after the operation were extracted for post hoc testa tests.

Conclusion

A group of obese patients undergoing LSG surgery were selected as the experimental group and a group of gastric cancer patients undergoing gastric sinus surgery as a control group. Both groups were frothefrom endangered clinical patients in Xijing Hospital. The age, weight, gender, waist circumference, food addiction scale scores, and Hamilton anxiety and depression scales of the two groups were investigated before and during the experiment.

Based on the DPARSF software of MATLAB platfthe significantAcknowledgmentorm, ALFF analysis was performed on the data of preoperative and postoperative pretreatment of the two groups. The SPM software package was used to analyze the variance of the main effect of group and time to find the brain region with significantasignificantAcknowledgment are  Acknowledgments cross effect. Brain regions associated with obesity are extracted and defined as regions of interest. The ALFF value of the region of interest is then extracted for post hoc testing.

References

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9. Rosenthal RJ. International Sleeve Gastrectomy Expert Panel Consensus Statement: the MY  guidelines  Acknowledgmentbased on the  Realign theplate theexperience of ＞12,000 cases. Surgery for Obesity and Related Diseases, 2012; 8(1): 8-19.
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