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pharm ch5 sympathomiometic/anticholinergic drugs SABA/LABA,SAMA/LAMA. Essay

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Generic Name: Albuteral
what are the trade names?
Proventil, Ventolin, ProAir, etc

Type drug of Albuterol
Short acting beta agonist (SABA)

Indications for Albuterol
Rescue drug for bronchospasm, asthma, and COPD exacerbation, and maintenance drug for asthma and COPD.

Delivery method of albuterol
SVN and pMDI

Standard dose of albuterol
pMDI 2 puffs
SVN 2.5mg; 0.5ml of 0.5% solution

Duration of albuterol
4-6 hours

Frequency of albuterol
QID? Q 4 hr

onset of action of albuterol
5-15 min

Peak effect of albuterol
30-60 min

albuterol is available as?
syrup, tablets, extended release tablets

Why is Albuterol referred to as a racemic
Albuterol contains R & S isomers
R isomer is the potent isomer in albuterol and has few side effects.


S isomer is thought to be inert, but takes up space on receptor site.
May cause bronchoconstriction

Generic name: Salmeterol xinafoate
What is the Trade Name
Serevent

What type drug is (G.)Salmeterol Xinafoate/ (T.) Serevent
LABA long acting beta agonist

Delivery Method of (G) Salmeterol Xinafoate/ (T) Serevent
Diskus DPI pMDI

Duration of (G) salmeterol Xinafoate/ (T) Serevent
12 hours (LABA)

Frequency of Salmeterol Xinafoate/ (T) serevent
BID

Is Salmeterol Xinafoate/ (T) serevent a Rescue Drug?
why or why not
NO. Not for use during acute exacerbations. All LABA, 12+ hour increase risk for sudden death from asthma complications when used alone.

Generic Name Levalbuterol. What is trade name?
Xopenex

what type drug is (G) Levalbuterol/ (T) Xopenex
SABA short acting beta agonist

Indications for (G) levalbuterol/ (T) Xopenex
Rescue drug for bronchospasm, asthma, and COPD exacerbation.
Maintenance drug for asthma and COPD

Delivery Method for (G) levalbuterol/ (T) Xopenex
SVN pMDI

Duration of (G) levalbuterol/ (T) xopenex
3-8 hours

Frequency of (G) levalbuterol/ (T) xopenex
q 4-6 hr

What is special about levalbuterol compared to albuterol?
Levalbuterol is the R isomer of albuterol, therefore it is more potent and has fewer side effects.

Generic name: Formoterol, fumarate
Trade name?
Foradil, DPI perforomist SVN

What type drug is Formoterol, Fumarate?
(T) foradil, DPI perforomist SVN
Long acting Beta agonist LABA

Indications for (G) Formoterol (T) foradil DPI Perforomist (SVN)
maintenance drug for asthma and COPD to PREVENT acute exacerbations
Prevent EIA ( exercise induced asthma)

Delivery method of (G) formoterol (T) foradil DPI Perforomist (SVN)
Duration?
aerolizer DPI, SVN
12 hr

T/F LABA can be a rescue drug or maintenance
FALSE, repeated dosing causes an accumulation effect that can be toxic

Generic name: Aformoterol tartrate
Trade Name?
Brovana

(G) aformoterol tartrate (T) Brovana
type drug?
Indication?
LABA long acting beta agonist
maintenance drug for pts w/ COPD

(G) aformoterol tartrate (T) Brovana
Delivery method?
Duration?
SVN, 12 hrs

T/F aformoterol is less potent than Formoterol
False Aformoterol tartrate/ Brovana is the R isomer of Formoterol which means it is more potent and has fewer side effects.

Generic Olodaterol
Trade Name?
Striverdi

(G) Olodaterol/ (T) Striverdi
type drug?
Indication?
LABA, long acting Beta Agonist
maintenance drug for pts w/ COPD
***not intended for pts w/ asthma @ this time

(G) olodaterol/ (T) Striverdi
Delivery method?
Duration?
Respimat Inhaler/ SMI/ Slow mist inhaler
24 hrs

Generic – Indacaterol Maleate
What is trade name?
Arcapta

(G) Indacaterol Maleate (T) Arcapta
Type drug?
Indication?
LABA long acting beta agonist
maintenance drug for pts w/ COPD
**not intended use w/ pts w/ asthma at this time

(G) Indacaterol Maleate (T) Arcapta
Delivery Method?
Duration?
Neohaler DPI
24 hr

How are Bronchial smooth muscles stimulated
Bronchial smooth muscles are stimulated by sympathetic hormones (Catecholamines) circulating in the blood

How do sympathomimetic (Beta-adrenergic) drugs work
sympathomi drugs directly cause bronchodilation by increasing cyclic AMP (cAMP) which cause bronchodilation (EX albuterol)

How do anticholinergic (Parasympatholytic) drugs work
aka muscarinic antagonist
block bronchoconstricting effeects of cyclic GMP (cGMP) substance produced by parasympathetic system that causes bronchoconstriction

when is racemic epinephrine (Vaponefrin, Micronefrin) used?
Commonly used for alpha properities
topical vasoconstrictor for treating airway edema
croup & laryngeal edema (post-extubation stridor)

Generic Name:
Ipratropium Bromide
what is trade name
Atrovent

(G) Ipratropium Bromide/ (T) Atrovent
Type drug?
Indication?
Anticholinergic, Short acting muscarinic antagonist, SAMA
Maintenance TREATMENT of bronchospasm in COPD

(G) ipratropium bromide/ (T) atrovent
delivery method?
Duration?
SVN, pMDI-HFA
pMDI-HFA 2 puffs (17mcg/puff)
SVN, 0.5 mg in 2.5 ml unit dose
4-6 hr

T/F atrovent and albuterol have a synergistic relationship
True

what is one contraindication for iproprium bromide/atrovent
Contraindicated with pts with hypersensitivity to soy lecithin
ask about peanut or soy allergies before admin

(G)Tiotropium Bromide
Trade name
Spiriva

(G) tiotropium Bromide (T) Spiriva
type drug?
Indications
LAMA long acting muscarinic antagonist
Maintenance drug for COPD and asthma

(G) tiotropium Bromide (T) spiriva
Delivery Method
Duration
handi-haler, DPI; Respimat, SMI
24 hrs

(G) aclidinium Bromide
trade name?
Tudoroza

(G) aclidinium Bromide (T) Tudoroza
Type drug
Indication
LAMA long acting muscarinic antagonist
maintenance drug for COPD

(G) Aclidinium Bromide (T) Tudoroza
Delivery method
Duration
Pressair, DPI inhaler
12 hr

(G) Glycopyrronium Bromide
Trade Name
Seebri

(G) Glycopyrronium Bromide (T) Seebri
type drug
indication
LAMA long acting muscarinic antagonist
maintenance drug for COPD

(G) Glycoppyrronium Bromide (T) Seebri
delivery method
duration
Breezhaler, DPI similar to neohaler
12 hr

(G) umeclidinium
trade name
Incruse

(G) umeclidinium (T) incruse
type drug
indications
LAMA Long acting muscarinic antagonist
maintenance drug for COPD

(G) umeclidinium (T) incruse
Delivery Method
Duration
Ellipta, DPI
24 hr

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pharm ch5 sympathomiometic/anticholinergic drugs SABA/LABA,SAMA/LAMA.. (2018, Jan 05). Retrieved from https://studymoose.com/pharm-ch5-sympathomiometicanticholinergic-drugs-sabalabasamalama-essay

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