Haven't found the Essay You Want?
For Only $12.90/page

Fexofenadine Essay Topics & Paper Examples

Fexofenadine Drug Monograph

An anti-histamine gaining popularity nowadays is Fexofenadine Hydrochloride. Its brand names include Allegra, Telfast and Fastofen. It has been categorized both under second- (1) and third-generation (2) anti-histamines, which acts as a Histamine-1 receptor antagonist, however being modified to not easily cross the blood-brain barrier. With this, Fexofenadine causes less drowsiness, as compared to first-generation histamine-receptor antagonists (3). It’s systematic name (IUPAC) is 2-[4-[1-hydroxy-4-[4-(hydroxy-diphenyl- methyl)-1-piperidyl]butyl]phenyl]-2- methyl-propanoic acid (4). Figure 1 shows the chemical structure of the drug. Source: http://en. wikipedia. org/wiki/Fexofenadine It is a metabolite of Terfenadine, with a molecular weight of 538. 13. It is freely soluble in methanol and ethanol, slightly soluble in chloroform and water, and insoluble in hexane. Its empirical formula is C32H39NO4•HCl. This drug appears…